منابع مشابه
AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling
The up-regulation of ALL1-fused gene from chromosome 1q (AF1q) is commonly seen in aggressive hematologic malignancies as well as in several solid tumor tissues. However, its expression and intrinsic function in human colorectal cancer (CRC) remains largely undefined. To explore the role of AF1q in human CRC progression, AF1q expression was analyzed in human CRC tissue samples and CRC cell line...
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BACKGROUND Fenretinide (4-HPR) is a synthetic retinoid that exhibits potent antitumor and chemopreventive activities against different malignancies, including ovarian tumors. We previously showed that in ovarian cancer cells, 4-HPR induces apoptosis through a signaling cascade starting from reactive oxygen species (ROS) generation and involving endoplasmic reticulum (ER) stress response, Jun N-...
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Cytogenetic abnormalities including the gain and loss of chromosomes play an important role in oncogenesis. Aberrations involving chromosome 1 are one of the most common anomalies reported among human neoplasms and have been observed in both solid tumors and hematological malignancies. This review highlights the prognostic import of cytogenetic abnormalities involving 1q in childhood cancers an...
متن کاملIs schizophrenia linked to chromosome 1q?
Chromosome 1q? Levinson et al. (1) reported the results of a meta-analysis of families showing no major schizophrenia locus on chromosome 1q. These results, based on a multicenter study of affected sibling pairs (ASPs), are in striking contrast to findings of several recent papers reporting susceptibility loci on 1q in extended families. Significant linkage (LOD 6.5) at 1q21-22 was detected in ...
متن کاملLoss of heterozygosity on chromosome 1q in human breast cancer.
Cytogenetic markers involving the long arm of chromosome 1 are the most frequently observed karyotypic changes seen in breast cancer. Based on cytogenetic data, we have used polymorphic DNA markers to search for allelic losses at this chromosome region among 48 breast carcinomas. For SPTA1, allelic losses were seen in 6 of 26 (23%) informative carcinomas, while 3 of 13 (23%) and 5 of 19 (26%) i...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37426